参考文献 References
[1] 中华医学会糖尿病学分会. 中国糖尿病防治指南（2024版）[J]. 中华糖尿病杂志,2025,17(1):16-139.
[2] XU Y, LU J, LI M, et al. Diabetes in China part 1: epidemiology and risk factors[J]. Lancet Public Health, 2024,9(12):e1089-e1097.
[3] HAMEED I, MASOODI S R, MIR S A, et al. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition[J]. World J Diabetes, 2015,6(4):598-612.
[4] YANG Z, ZHANG L, LIU J, et al. Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism[J]. Antioxidants (Basel), 2024,13(4)
[5] 郁娃林, 赵丹青, 曹雯,等. 肠道菌群代谢物影响2型糖尿病发生发展分子机制的研究进展[J]. 激光生物学报,2025,34(2):113-120.
[6] 蒋晓玉, 赵媛媛, 李飞,等. 基于“肠–肝”轴学说探讨肠道菌群在代谢性疾病中的作用[J]. 药物资讯,2024, 13(3):149-161.
[7] 张博荀, 赵林华, 金籽杉,等. 2型糖尿病"郁-热"病机与肠道菌群关系的思考[J]. 中国中医基础医学杂志,2022, 28(8):1286-1289.
[8] 汲晓玲, 周游, 李泽浩,等. 大柴胡汤历史沿革、临床应用和药理作用研究进展及其质量标志物预测分析[J]. 中国中药杂志,2024,49(8):2064-2075.
[9] 张卫欢, 李秋云, 杨春伟,等. 大柴胡汤加减联合利拉鲁肽对肥胖2型糖尿病患者胰岛素抵抗、β-细胞功能和低度炎症反应的影响[J]. 现代中西医结合杂志,2018,27(1):23-26,30.
[10] Zhang Z, Leng Y, Fu X, et al. The efficacy and safety of dachaihu decoction in the treatment of type 2 diabetes mellitus: A systematic review and meta-analysis. Front Pharmacol. 2022;13:918681. Published 2022 Aug 8. doi:10.3389/fphar.2022.918681
[11] CUI H, LI Y, WANG Y, et al. Da-Chai-Hu Decoction Ameliorates High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Remodeling the Gut Microbiota and Modulating the Serum Metabolism[J]. Front Pharmacol, 2020,11:584090.
[12] QIN J, LI Y, CAI Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. Nature, 2012,490(7418):55-60.
[13] KARLSSON F H, TREMAROLI V, NOOKAEW I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control[J]. Nature, 2013,498(7452):99-103.
[14] AHMAD A, YANG W, CHEN G, et al. Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals[J]. PLoS One, 2019,14(12):e0226372.
[15] LI Q, CHANG Y, ZHANG K, et al. Implication of the gut microbiome composition of type 2 diabetic patients from northern China[J]. Sci Rep, 2020,10(1):5450.
[16] FORSLUND K, HILDEBRAND F, NIELSEN T, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J]. Nature, 2015,528(7581):262-266.
[17] CHEN P C, CHIEN Y W, YANG S C. The alteration of gut microbiota in newly diagnosed type 2 diabetic patients[J]. Nutrition, 2019,63-64:51-56.
[18] GAIKE A H, PAUL D, BHUTE S, et al. The Gut Microbial Diversity of Newly Diagnosed Diabetics but Not of Prediabetics Is Significantly Different from That of Healthy Nondiabetics[J]. mSystems, 2020,5(2):e00578-00519.
[19] CRUDELE L, GADALETA R M, CARIELLO M, et al. Gut microbiota in the pathogenesis and therapeutic approaches of diabetes[J]. EBioMedicine, 2023,97:104821.
[20] TOLHURST G, HEFFRON H, LAM Y S, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2[J]. Diabetes, 2012,61(2):364-371.
[21] WANG J, ZHAO Q, ZHANG S, et al. Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)[J]. Int J Mol Med, 2026,57(1)
[22] LIN M Y, DE ZOETE M R, VAN PUTTEN J P, et al. Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases[J]. Front Immunol, 2015,6:554.
[23] 项青青, 赖凤, 肖虹,等. 大柴胡汤缓解葡聚糖硫酸钠诱导的溃疡性结肠炎及肝损伤并与其对小鼠肠道菌群的调控作用相关[J]. 重庆医科大学学报,2025,50(8):1084-1095.
[24] GAO R, MENG X, XUE Y, et al. Bile acids-gut microbiota crosstalk contributes to the improvement of type 2 diabetes mellitus[J]. Front Pharmacol, 2022,13:1027212.
[25] TAWULIE D, JIN L, SHANG X, et al. Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism[J]. Phytomedicine, 2023,113:154733.
[26] WANG Y, YU J, CHEN B, et al. Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis[J]. Front Endocrinol (Lausanne), 2024,15:1481270.
[27] PAN T, LI X, GUO X, et al. Electroacupuncture Improves Insulin Resistance in Type 2 Diabetes Mice by Regulating Intestinal Flora and Bile Acid[J]. Diabetes Metab Syndr Obes, 2023,16:4025-4042.
[28] WANG R, JIA F, ZHAO Z, et al. Dachaihu decoction inhibits hypernutrition-induced liver metastasis from colorectal cancer by maintaining the gut vascular barrier[J]. Cancer Pathog Ther, 2023,1(2):98-110.
[29] 缪辉来, 林木生, 张利强,等. 加味大柴胡汤对阻塞性黄疸大鼠胆汁酸代谢的影响及机制[J]. 中华实验外科杂志,2006,23(8):934-936.
[30] HUANG Y, WU Y, ZHANG Y, et al. Dynamic Changes in Gut Microbiota-Derived Metabolite Trimethylamine-N-Oxide and Risk of Type 2 Diabetes Mellitus: Potential for Dietary Changes in Diabetes Prevention[J]. Nutrients, 2024,16(11):1711.
[31] 姜晓静. TMAO在胰岛β细胞功能障碍中的作用和机制研究[D] ,2024.
[32] 戚宇琪, 郭杰. 基于内毒素血症学说探讨肠道菌群紊乱导致2型糖尿病的发病机制[J]. 世界最新医学信息文摘（连续型电子期刊）,2019,19(63):85-86.
[33] HE Z, GUO J, ZHANG H, et al. Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites[J]. Int J Biol Macromol, 2023,253(Pt 4):126987.
[34] LU J, HUANG Y, ZHANG Y, et al. Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice[J]. Front Nutr, 2025,12:1574792.
[35] 瞿岳云. 消渴不可概以阴虚燥热论[J]. 中国中医基础医学杂志,2006,12(3):198-201.
[36] 何雷, 唐雪梅. 肝失疏泄与糖尿病的相关性探讨[J]. 环球中医药,2016,9(4):438-440.
[37] LI L, YANG S, LIANG X, et al. Saikosaponin D improves nonalcoholic fatty liver disease via gut microbiota-bile acid metabolism pathway[J]. Food Science and Human Wellness, 2024,13(5):2703-2717.
[38] GU Y, DUAN S, DING M, et al. Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway[J]. Phytomedicine, 2022,103:154219.
[39] FENG J, MA H, YUE Y, et al. Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens[J]. POULTRY SCIENCE, 2023,102(12):103155.
[40] WU L, YAN Q, CHEN F, et al. Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway[J]. BIOMEDICINE & PHARMACOTHERAPY, 2021,135(2):111187.
[41] FENG Y, WENG H, LING L, et al. Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice[J]. International Journal of Biological Macromolecules, 2019
[42] ZHANG A, GAO S, SHEN C, et al. Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin via regulating intestinal β-glucuronidase activity in MASH mice[J]. PHYTOMEDICINE, 2010,145(000):16.
[43] SHIN N R, GU N, CHOI H, et al. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of type 2 diabetes patients via gut microbiota modulation[J]. AJP Endocrinology and Metabolism, 2019,318(1)
[44] ZHANG, BOWEI, SUN, et al. Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats[J]. Journal of Functional Foods, 2018
[45] JU M, LIU Y, LI M, et al. Baicalin improves intestinal microecology and abnormal metabolism induced by high-fat diet[J]. European Journal of Pharmacology, 2019,857:172457.
[46] CHEN L, LIU E, ZHAO X, et al. Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress[J]. Frontiers in Pharmacology, 2025,16(000).
[47] WEI Z, SHEN P, CHENG P, et al. Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits[J]. Oxidative medicine and cellular longevity, 2020,2020:1-16.
[48] LE J, ZHANG X, JIA W, et al. Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice[J]. Acta Pharmaceutica Sinica B, 2019,9(4):758-768.
[49] CUI H, ZHANG L, LUO Y, et al. A Purified Anthraquinone-Glycoside Preparation From Rhubarb Ameliorates Type 2 Diabetes Mellitus by Modulating the Gut Microbiota and Reducing Inflammation[J]. Frontiers in Microbiology, 2019,10
[50] ZENG Y Q, DAI Z, LU F, et al. Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease[J]. Oncotarget, 2016,7(14):17468-17478.
[51] ZHANG J, KANG H, WANG L, et al. Chrysophanol ameliorates high-fat diet-induced obesity and inflammation in neonatal rats[J]. Pharmazie, 2018,73(4):228-233.
[52] VALERII M C, TURRONI S, FERRERI C, et al. Effect of a Fiber D-Limonene-Enriched Food Supplement on Intestinal Microbiota and Metabolic Parameters of Mice on a High-Fat Diet[J]. Pharmaceutics, 2021,13(11):1753.
[53] LIU T, LEI C, HUANG Q, et al. Hesperidin and Fecal Microbiota Transplantation Modulate the Composition of the Gut Microbiota and Reduce Obesity in High Fat Diet Mice[J]. Diabetes Metab Syndr Obes, 2024,17:3643-3656.
[54] ZHANG D, HE X, JIANG H, et al. Hesperetin-Attenuated Diabetes-Induced Vascular Endothelial Injury, Associated with Gut Microbiota Modulation and Cholesterol Homeostasis[J]. J Agric Food Chem, 2025,73(44):28202-28216.
[55] LUO C, YANG D, HOU C, et al. Paeoniflorin protects NOD mice from T1D through regulating gut microbiota and TLR4 mediated myD88/TRIF pathway[J]. Exp Cell Res, 2023,422(1):113429.
[56] OU X, YU Z, PAN C, et al. Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes[J]. Front Pharmacol, 2025,16:1551368.
[57] KIM Y J, SHIN Y O, HA Y W, et al. Anti-obesity effect of Pinellia ternata extract in Zucker rats[J]. Biol Pharm Bull, 2006,29(6):1278-1281.
[58] ALHAMOUD Y, AHMAD M I, ABUDUMIJITI T, et al. 6-Gingerol, an active ingredient of ginger, reshapes gut microbiota and serum metabolites in HFD-induced obese mice[J]. Journal of Functional Foods, 2023,109(000):12.
[59] WANG K, KONG L, WEN X, et al. The Positive Effect of 6-Gingerol on High-Fat Diet and Streptozotocin-Induced Prediabetic Mice: Potential Pathways and Underlying Mechanisms[J]. Nutrients, 2023,15(4):824.
[60] JIAO W, SANG Y, WANG X, et al. Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity[J]. Food Chem, 2023,404(Pt B):134734.
[61] CHE X, ZHAO Y, WANG Y, et al. Modulatory effects of black jujube melanoidins on gut microbiota and metabolic pathways in high-fat diet-induced obesity[J]. Front Nutr, 2025,12:1580439.
[62] JIAO L, ZOU J, MA H, et al. Regulatory effects of jujube (Ziziphus jujuba) polysaccharides on intestinal microbiota before and after α-galactosidase-mediated degradation[J]. Food Funct, 2026,17(2):930-941.