摘要
目的 探索徐永昌教授运用赞育丹合并五子衍宗丸治疗阳痿肾虚证型的临床疗效及应用价值。方法 利用随机数字表法将本院收治的156例阳痿肾虚证型患者（2024年4月至2025年4月）均分两组（各78例）：治疗组采用赞育丹合并五子衍宗丸加减治疗，对照组采用采用赞育丹原方治疗。观察患者治疗前后国际勃起功能指数-5（IIEF-5）评分、中医证候积分变化，统计临床总有效率。结果 治疗前两组中医症候积分、IIEF-5评分接近（P>0.05），治疗后两组中医症候积分均下降而IIEF-5评分均升高，且组间对比显示治疗组的中医症候积分更低而IIEF-5评分更高（P<0.05）。相比对照组，治疗组的治疗总有效率明显更高（94.87% vs.79.49%，P<0.05）。结论 徐永昌教授运用赞育丹合并五子衍宗丸治疗阳痿肾虚证型，能有效改善患者勃起功能，缓解肾虚相关证候，临床疗效确切。
关键词： 赞育丹；五子衍宗丸；阳痿；肾虚证型；IIEF-5评分；中医证候
Abstract
Objective To explore the clinical efficacy and application value of Professor Xu Yongchang's treatment of impotence with kidney deficiency syndrome using Zanyudan combined with Wuzi Yanzong Wan. Methods 156 patients with impotence with kidney deficiency syndrome admitted to our hospital (April 2024 to April 2025) were randomly divided into two groups (78 cases in each group): the treatment group received Zanyudan combined with Wuzi Yanzong Wan with modifications, while the control group received the original Zanyudan formula. Changes in the International Index of Erectile Function-5 (IIEF-5) score and TCM syndrome score before and after treatment were observed, and the total clinical effective rate was statistically analyzed. Results Before treatment, the TCM syndrome scores and IIEF-5 scores of the two groups were similar (P>0.05). After treatment, the TCM syndrome scores of both groups decreased while the IIEF-5 scores increased. Furthermore, the treatment group showed a lower TCM syndrome score and a higher IIEF-5 score (P<0.05). Compared with the control group, the total effective rate of the treatment group was significantly higher (94.87% vs. 79.49%, P<0.05). Conclusion Professor Xu Yongchang's use of Zanyudan combined with Wuzi Yanzong Wan to treat impotence with kidney deficiency syndrome can effectively improve patients' erectile function and alleviate kidney deficiency-related symptoms, demonstrating definite clinical efficacy.
Key words： Zanyudan; Wuzi yanzong wan; Impotence; Kidney deficiency syndrome; IIEF-5 score; TCM syndrome
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