A brief discussion on the causes and remedial measures of cracks in several tissue slices
浅谈几种组织切片裂隙产生的原因和补救措施

摘要

病理诊断是现代医学绝大部分疾病，尤其是肿瘤疾病诊断的“金标准”，但病理诊断的准确性受限于多种因素，其中病理组织切片的优劣是病理诊断工作的根基，而组织切片裂隙是严重影响病理医生判读的重大痼疾。此类裂隙易干扰病变特征识别，加剧诊断难度，为避免误诊、漏诊的发生，必须多角度、多层面地剖析组织切片裂隙产生的原因并对症补救，以确保病理诊断的准确性。本文从易造成切片裂隙现象的组织种类入手，深入探究病理组织切片裂隙产生的原因，并结合笔者多年的实践经验，总结归纳出了组织切片裂隙产生后的几种补救措施。

Abstract

Pathological diagnosis is the “gold standard” for the diagnosis of most diseases in modern medicine, especially tumor diseases. However, the accuracy of pathological diagnosis is limited by various factors, among which the quality of pathological tissue slices is the foundation of pathological diagnosis work, and tissue slice fissures are a major chronic disease that seriously affects pathologists' interpretation. To avoid misdiagnosis and missed diagnosis, it is necessary to analyze the causes of tissue slice fissures from multiple angles and multiple layers, and provide targeted remedies to ensure the accuracy of pathological diagnosis. This article starts with the types of tissues that are prone to causing slice fissures, explores in depth the causes of pathological tissue slice fissures, and summarizes several remedial measures for tissue slice fissures based on the author’s years of practical experience.