摘要
目的 评价乌梅洋参茶干预气阴两虚型盗汗的临床疗效，并探讨其对患者中医证候和盗汗程度的影响，为其临床应用提供依据。方法 选取60例气阴两虚型盗汗症患者，随机分为对照组和干预组，每组30例。对照组口服生脉颗粒，干预组服用乌梅洋参茶，两组均连续干预15天。比较两组患者临床疗效、盗汗严重程度（HDSS分级）、中医证候评分及治疗前后红细胞沉降率（ESR）和C反应蛋白（CRP）水平的变化。结果 干预后，干预组的临床总有效率（96.7%）高于对照组（73.3%），差异有统计学意义（P<0.05）。在中医证候改善方面，干预后两组评分均显著降低（P<0.01），且干预组在“口渴喜饮”和“气短懒言”症状上的改善幅度显著优于对照组（P<0.01）。在生化指标上，两组ESR和CRP水平均显著下降（P<0.01），且干预组的降幅明显大于对照组。结论 乌梅洋参茶能有效改善气阴两虚型盗汗患者的临床症状，尤其在缓解口渴喜饮、气短懒言等核心证候及降低系统性炎症水平方面，效果更优，是一种安全有效的干预方案。
关键词： 乌梅洋参茶；气阴两虚型；盗汗症
Abstract
Objective To evaluate the clinical efficacy of Wumei Yangshen Tea in the intervention of night sweats syndrome of the qi and yin deficiency type, and to explore its effects on patients' Traditional Chinese Medicine (TCM) syndromes and the severity of night sweats, so as to provide evidence for its clinical application. Methods A total of 60 patients with night sweats syndrome of the qi and yin deficiency type were selected and randomly divided into a control group and an intervention group, with 30 cases in each group. The control group was treated with Shengmai Granules, while the intervention group received Wumei Yangshen Tea. Both groups underwent continuous intervention for 15 days. The clinical efficacy, severity of night sweats (HDSS grading), TCM syndrome scores, and the changes in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels before and after treatment were compared between the two groups. Results After the intervention, the total clinical effective rate in the intervention group (96.7%) was higher than that in the control group (73.3%), and the difference was statistically significant (P<0.05). In terms of TCM syndrome improvement, the scores in both groups decreased significantly after the intervention (P<0.01), and the improvement in the symptoms of “thirst and preference for drink” and “shortness of breath and disinclination to talk” in the intervention group was significantly greater than that in the control group (P<0.01). Regarding biochemical indicators, the levels of ESR and CRP in both groups decreased significantly (P<0.01), and the magnitude of reduction in the intervention group was markedly greater than that in the control group. Conclusion Wumei Yangshen Tea can effectively improve the clinical symptoms of patients with night sweats syndrome of the qi and yin deficiency type. It demonstrates superior efficacy, particularly in alleviating core syndromes such as thirst and shortness of breath, and in reducing systemic inflammation levels, making it a safe and effective intervention plan.
Key words： Wumei Yangshen tea; Qi and Yin deficiency type; Night sweats syndrome
参考文献 References
[1] Mold JW, Goodrich S, Orr W. Associations between subjective night sweats and sleep study findings[J]. The Journal of the American Board of Family Medicine, 2008, 21(2): 96-100.
[2] 许福丽,范金茹,毛小静,等.王行宽教授应用柴芪生脉散治疗盗汗经验[J].湖南中医药大学学报,2019,39(11): 1340-1342.
[3] 叶蓝月,祁禹德,陈宝贵,等.陈宝贵教授治疗汗证经验举隅[J].天津中医药,2022,39(06):697-700.
[4] Yuksel N, Evaniuk D, Huang L, et al. Guideline No. 422a: Menopause: vasomotor symptoms, prescription therapeutic agents, complementary and alternative medicine, nutrition, and lifestyle[J]. Journal of obstetrics and gynaecology Canada, 2021, 43(10): 1188-1204.
[5] Richard-Davis G, Ajmera M, Shiozawa A, et al. Health disparities in vasomotor symptom prevalence and treatment discontinuation in women of menopausal age: a commercial claims analysis[J]. Journal of Women's Health, 2025, 34(2): 176-186.
[6] 赵诚和,谢雅之,周韶梅,等.中医食疗系列方改善肿瘤患者化疗期间症状临床观察[J].世界科学技术-中医药现代化,2017,19(4):663-668.
[7] Wachiraporn P, Wang Y, Guo HY, et al. Analysis of the clinical therapeutic effect of Professor Wang Yue on 42 cases of Sjogren's syndrome overlaps with Hashimoto's thyroiditis[J]. Journal of Health Science and Alternative Medicine,2022:65-68.
[8] Huang AJ, Faubion S, Grady D. Nonhormonal Treatment of Menopausal Vasomotor Symptoms[J]. JAMA Internal Medicine, 2025,185(7): 874–875.
[9] 郑筱萸.中药新药临床研究指导原则[M].北京中国医药科技出版社,2002.
[10] 中华人民共和国中医药行业标准．中医病证诊断疗效标准[M].南京：南京大学出版社.1994：20.
[11] Shi M, Ma J, Jin S, et al. Effects of saponins Rb1 and Re in American ginseng combined intervention on immune system of aging model[J]. Frontiers in Molecular Biosciences, 2024, 11: 1392868.
[12] Zhang X, Li L, Chen T, et al. Research progress in the effect of traditional Chinese medicine for invigoration on neurotransmitter related diseases[J]. Evidence‐Based Complementary and Alternative Medicine, 2018, 2018(1): 4642018.
[13] Liu R, Zhao X, Zhu Y, et al. Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury Authors[J]. Frontiers in Aging Neuroscience, 2025, 17: 1555067.
[14] Guoliang L, Feng R, Yu J, et al. Ophiopogon japonicus (L. f.) Ker Gawl. extract treats dry eye disease via anti-inflammatory, antioxidant, and goblet cell-stimulating effects[J]. Journal of Traditional Chinese Medical Sciences, 2025.
[15] Tang H, Zhou B, Liu R, et al. Ultrasound‐Microwave Associated Extraction of Anthocyanins From Mulberry and Their Antioxidant and Anticancer Activities[J]. Food Science & Nutrition, 2025, 13(10): e71022.
[16] 任娜,韩秀珍,刘溦溦,等.乌梅丸及其单味药有效成分在消化系统疾病中的研究进展[J].中华中医药学刊,2025, 43(01):128-133.