Clinical observation on the efficacy of Jueming Chrysanthemum tea in the intervention of dizziness, headache, and dry eye syndrome with liver-fire flaming upward
决明菊花茶干预肝火上炎型头晕头痛和干眼症的临床疗效观察

摘要

目的 评价决明菊花茶干预肝火上炎型头晕头痛合并干眼症患者的临床疗效。方法 选取136例肝火上炎型头晕头痛合并干眼症患者，随机分为对照组和干预组，各68例。对照组口服盐酸氟桂利嗪胶囊并联合玻璃酸钠滴眼液治疗；干预组在玻璃酸钠滴眼液治疗基础上，配合决明菊花茶干预。两组均持续治疗2周。比较两组临床总有效率，采用视觉模拟评分法（VAS） 评价患者头痛程度，采用泪膜破裂时间（TBUT）和泪液基础分泌试验（SIT）评估患者干眼症改善效果，并评估中医证候的变化。结果 干预后，干预组的临床总有效率为94.1%，显著高于对照组的66.2%（P<0.001）。两组患者的VAS评分、TBUT和SIT均较治疗前显著改善（P<0.01），且干预组的改善幅度均显著优于对照组（P<0.01）。干预组患者的中医证候评分（目赤、急躁易怒、口苦咽干、大便秘结、舌质红、舌苔黄）在治疗后均显著降低（P<0.01）。结论 决明菊花茶能有效改善肝火上炎型头晕头痛合并干眼症患者的临床症状、眼表功能及中医证候，临床疗效显著。

Abstract

Objective To evaluate the clinical efficacy of Jueming Chrysanthemum tea in the intervention of patients with dizziness, headache, and dry eye syndrome characterized by liver-fire flaming upward.
Methods A total of 136 patients with dizziness, headache, and dry eye syndrome characterized by liver-fire flaming upward were selected and randomly divided into a control group and an intervention group, with 68 cases in each group. The control group was treated with oral Flunarizine Hydrochloride capsules combined with sodium hyaluronate eye drops. The intervention group was treated with Jueming Chrysanthemum tea on the basis of sodium hyaluronate eye drops. Both groups were treated continuously for 2 weeks. The total clinical effective rate of the two groups was compared. The degree of headache was evaluated using the Visual Analogue Scale (VAS). The improvement of dry eye syndrome was assessed by Tear Break-up Time (TBUT) and Schirmer’s Test (SIT). The changes in Traditional Chinese Medicine (TCM) syndromes were also evaluated.
Results After the intervention, the total clinical effective rate of the intervention group was 94.1%, which was significantly higher than that of the control group (66.2%) (P<0.001). The VAS scores, TBUT, and SIT of both groups were significantly improved compared with those before treatment (P<0.01), and the improvement in the intervention group was significantly better than that in the control group (P<0.01). The TCM syndrome scores of the intervention group (red eyes, irritability, bitter taste in the mouth and dry throat, constipation, red tongue body, and yellow tongue coating) were significantly decreased after treatment (P<0.01).
Conclusion   Jueming Chrysanthemum tea can effectively improve the clinical symptoms, ocular surface function, and TCM syndromes of patients with dizziness, headache, and dry eye syndrome characterized by liver-fire flaming upward, showing significant clinical efficacy.