Preparation of sunscreen lotion and evaluation of its efficacy by physical-chemical combination of phellodendron -complexed lignin/titanium dioxide nanocomposite particles based on liposome technology
基于脂质体技术的黄柏复配木质素TiO2纳米复合粒子的物化结合防晒乳的制备及其功效性评价

摘要

目的 近年来，海洋生态系统不断遭到破坏，而市面上大部分的防晒乳都含有污染海洋环境的化学成分。此外，普通的防晒乳还存在着防紫外波长有限、防晒时间短、皮肤刺激性高等缺点；基于此，本项目利用了具有吸收紫外线能力的传统中药材黄柏合成温和亲肤的中药脂质体并结合AL-PDA/TiO2复合纳米粒子制备一款不添加香精、防腐剂的绿色健康的物化双效抗紫外防晒乳。希望能为利用植物活性制备防晒乳提供新思路。方法 我们采取索氏提取法对黄柏进行有效成分提取并用薄膜分散法将其制成黄柏脂质体作为化学抗紫外剂。随后将多巴胺修饰在木质素表面利用超声化学法合成AL-PDA/TiO2作为物理抗紫外剂。最后利用正交实验、质量评价等实验完成物化双效抗紫外防晒乳配方设计。结果 通过对材料的表征以及对防晒乳进行质量、功效、感官等多维度评估分析，本实验得出黄柏防晒脂质体添加量18%，AL-PDA/TiO2复合纳米粒子添加量为15%时，实验防晒乳具有良好感受、外观、抗紫外能力，为本实验防晒乳最佳配方。结论 实验制备出的防晒乳经过多项测试均达到令人满意的效果，且制备原材料简单，价格低昂，防晒效果佳，具有良好可行性以及应用前景，有望成为市面上新体系防晒乳。

Abstract

Objective In recent years, the marine ecosystem has been continuously damaged, and most of the sunscreen lotions on the market contain chemical ingredients that pollute the marine environment. In addition, ordinary sunscreen lotions have the disadvantages of limited protection against ultraviolet wavelengths, short duration of sun protection and skin irritation; Based on this, this project utilizes the traditional Chinese medicine phellodendron, which has the ability to absorb ultraviolet rays, to synthesize mild and skin-friendly traditional Chinese medicine liposomes and combines them with AL-PDA/TiO2 composite nanoparticles to prepare a green and healthy physical and chemical dual-acting anti-ultraviolet sunscreen lotion with no added flavors and preservatives. It is hoped that this will provide new ideas for the preparation of sunscreen lotions using plant activities.
Methods The active ingredients of Phellodendron Bark were extracted by Soxhlet extraction and made into Phellodendron Bark liposomes as chemical anti-UV agents by thin film dispersion method. Subsequently, we modified dopamine on the surface of lignin and synthesized AL-PDA/TiO2 as a physical anti-ultraviolet agent by ultrasonic chemical method. Finally, orthogonal experiments, quality evaluation and other experiments were used to complete the formulation design of the physical and chemical double-effect anti-UV sunscreen lotion.
Results Through the characterization of the materials and the multi-dimensional evaluation and analysis of the quality, efficacy and sensory of the sunscreen lotion, it was concluded in this experiment that the experimental sunscreen lotion with 18% of cypress sunscreen liposome addition and 15% of AL-PDA/TiO2 composite nanoparticle addition had good feeling, appearance, and UV-resistant ability, which were the best formulations for this experimental sunscreen lotion.
Conclusion   Experimentally prepared sunscreen milk after a number of tests have reached satisfactory results, and the preparation of simple raw materials, low price, good sunscreen effect, has a good feasibility as well as application prospects, is expected to become a new system of sunscreen milk on the market.