Clinical co-medication experience of recurrent aphthous ulcers
复发性阿弗他溃疡的临床联合用药体会

摘要

目的 总结治疗复发性阿弗他溃疡（RAU）的临床联合用药体会。方法 选择200名研究对象为自愿接受联合用药治疗口腔溃疡并按时复查的患者，均无药物过敏史。男89例，女111例，年龄15-68 （34.88±9.45）岁。全部患者按照疼痛表分级为微痛、较痛、非常痛，分别为A组为微痛，B组为较痛、C组、E组、D组为非常痛，各40例。各组患者年龄、性别、溃疡个数、面积等一般资料的比较差异无显著性（P>0.05）。按照RAU疼痛轻重度合理有效使用不同强度的药效组合，即治疗口腔溃疡的用药按照强度分组方法联合使用：止痛消炎药+溃疡面愈合药+补充维生素+清洁口腔漱口水。充分合理发挥药效。口腔溃疡自愈一般需要7-14天，口腔联合用药明显加快了溃疡愈合，但是不同程度的病症使用相应的药物强度，能够得到相同的治疗结果，若未对症合理给药，患者的不良反应明显，使用激素使身体肥胖等，这违背了治疗初衷。结果 本研究结果显示，对症合理的联合用药治疗阿弗他溃疡具有非常重要临床意义。结论 为了避免重复用药，外用药、内用药涂抹药膏、含漱可多途径对症合理给药，这是治疗RAU最优、最合理途径。

Abstract

Objective To summarise the clinical experience of combination medication in the treatment of recurrent aphthous ulcers (RAU).
Methods Two hundred study subjects were selected as patients who voluntarily accepted the combination of medications for the treatment of aphthous ulcers and were reviewed on time, and none of them had a history of drug allergy. There were 89 males and 111 females aged 15-68 (34.88±9.45) years. All the patients were graded according to the pain scale as slight pain, more pain, and very pain, which were slight pain in group A, more pain in group B, and very pain in groups C, E, and D. There were 40 patients in each group. The comparison of general information such as age, gender, number of ulcers and area of patients in each group was not significant (P>0.05). According to the RAU pain degree of severity of reasonable and effective use of different strength of the combination of drug effect, that is, the treatment of oral ulcers of drugs in accordance with the intensity of the grouping method of combined use: pain relieving and anti-inflammatory drugs + ulcer surface healing drugs + supplemental vitamins + clean mouth mouthwash. Full and rational use of the effectiveness of the drug. Self-healing of oral ulcers generally takes 7-14 days, oral combined medication significantly accelerated the healing of ulcers, but different degrees of disease using the appropriate strength of the drug, to be able to get the same therapeutic results, if not symptomatic and reasonable administration of medication, the patient's adverse reactions are obvious, the use of hormones to make the body obese, etc., which is contrary to the original intention of the treatment.
Results The results of this study show that the symptomatic and rational combination of drugs for the treatment of aphthous ulcer has a very important clinical significance.
Conclusion   In order to avoid duplication of medication, topical medication, internal medication applying ointment, and gargle can be given in multiple symptomatic and rational ways, which is the optimal and most reasonable way to treat RAU.